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Dr. Hans Knoop

Associate professor
Head of the Expert Centre for Chronic Fatigue
Department of Internal Medicine
Radboud University Nijmegen Medical Centre

For most people, fatigue is a ‘normal’ and sometimes pleasant state that is experienced regularly. However, fatigue can become a symptom when it is severe, chronic, and interfering with daily live. Chronic fatigue can be the result of a chronic illness, but when a somatic explanation is lacking, we sometimes speak of chronic fatigue syndrome (CFS).

I study chronic fatigue in both chronic illnesses and in CFS. My research focuses on the following areas:
– Possible determinants of chronic fatigue
– Development and implementation of cognitive behavioural interventions for chronic fatigue
– Mechanisms of change in behavioural interventions for fatigue

Key words
• Chronic fatigue in chronic illness
• Chronic fatigue syndrome
• Cognitive behavioural interventions
• Determinants and perpetuating factors of fatigue
• Mechanisms of change
• E-health treatments

Selection of Key Publications
Tummers M, Knoop H, Van Dam

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A, Bleijenberg G. Implementing a Minimal Intervention for Chronic Fatigue Syndrome in a Mental Health Centre: a Randomized Controlled Trial. Psychological Medicine 2012 Feb 21:1-11. [Epub ahead of print].

Wiborg JF, Knoop H, Frank LE, Bleijenberg G. Towards an evidence-based treatment model for cognitive behavioral interventions focusing onchronic fatigue syndrome. Journal of psychosomatic research 2012;72:399-404.

Knoop H, Van Kessel K, Moss-Morris R. Which cognitions and behaviours mediate the positive effect of cognitive behaviour therapy on fatigue in patients with Multiple Sclerosis? Psychol Med. 2012 ;42:205-213.

Gielissen MF, Wiborg JF, Verhagen CA, Knoop H, Bleijenberg G Examining the role of physical activity in reducing postcancer fatigue. Support Care Cancer 2012;20(7):1441-7.

Bleijenberg G, Knoop H. Chronic fatigue syndrome: where to PACE from here? Lancet 2011; 377:786-8.

Wiborg JF, Knoop H, Stulemeijer M, Prins JB, Bleijenberg G. How does cognitive behaviour therapy reduce fatigue in patients with chronic fatigue syndrome? The role of physical activity. Psychological Medicine 2010; 40:1281-1287.

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